Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105301
Title: | Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons | Authors: | Caldo-Silva, Adriana Furtado, Guilherme Eustáquio Chupel, Matheus Uba Bachi, André L. L. de Barros, Marcelo P. Neves, Rafael S. Marzetti, Emanuele Massart, Alain Teixeira, Ana Maria |
Keywords: | inflammaging; cognitive impairment; cytokines; protein intake; physical frailty | Issue Date: | 28-Mar-2021 | Publisher: | MDPI | Project: | UID/DTP/0413/2020 | Serial title, monograph or event: | Nutrients | Volume: | 13 | Issue: | 4 | Abstract: | Nowadays, it is accepted that the regular practice of exercise and branched-chain amino acids supplementation (BCAAs) can benefit the immune responses in older persons, prevent the occurrence of physical frailty (PF), cognitive decline, and aging-related comorbidities. However, the impact of their combination (as non-pharmacological interventions) in albumin and the inflammatory markers is not fully understood. Therefore, we investigated the effect of a 40-week multifactorial intervention [MIP, multicomponent exercise (ME) associated or not with BCAAs] on plasma levels of inflammatory markers and albumin in frail older persons (≥75 years old) living at residential care homes (RCH). This study consisted of a prospective, naturalistic, controlled clinical trial with four arms of multifactorial and experimental (interventions-wahshout-interventions) design. The intervention groups were ME + BCAAs (n = 8), ME (n = 7), BCAAs (n = 7), and control group (n = 13). Lower limb muscle-strength, cognitive profile, and PF tests were concomitantly evaluated with plasma levels of albumin, anti- and pro-inflammatory cytokines [Interleukin-10 (IL-10) and Tumor Necrosis Factor-alpha (TNF-α) respectively], TNF-α/IL-10 ratio, and myeloperoxidase (MPO) activity at four different time-points: Baseline (T1), after 16 weeks of multifactorial intervention (T2), then after a subsequent 8 weeks washout period (T3) and finally, after an additional 16 weeks of multifactorial intervention (T4). Improvement of cognitive profile and muscle strength-related albumin levels, as well as reduction in the TNF-α levels were found particularly in ME plus BCAAs group. No significant variations were observed over time for TNF-α/IL-10 ratio or MPO activity. Overall, the study showed that MIP triggered slight alterations in the inflammatory and physical function of the frail older participants, which could provide independence and higher quality of life for this population. | URI: | https://hdl.handle.net/10316/105301 | ISSN: | 2072-6643 | DOI: | 10.3390/nu13041106 | Rights: | openAccess |
Appears in Collections: | FCDEF - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Effect-of-trainingdetraining-phases-of-multicomponent-exercises-and-BCAA-supplementation-on-inflammatory-markers-and-albumin-levels-in-frail-older-personsNutrients.pdf | 643.1 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
16
checked on Aug 19, 2024
WEB OF SCIENCETM
Citations
13
checked on Aug 2, 2024
Page view(s)
97
checked on Aug 27, 2024
Download(s)
45
checked on Aug 27, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License