Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/105266
Título: | Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs | Autor: | Martins, Ana S. Batista de Carvalho, Ana L. M. Marques, Maria Paula M. Gil, Ana M |
Palavras-chave: | metal chelates; human osteosarcoma cells; palladium; platinum; spermine; NMR; metabolomics; endometabolome | Data: | 8-Ago-2021 | Editora: | MDPI | Projeto: | UIDB/50011/2020 UIDP/50011/2020 Centro-01-0145- FEDER-029956 UIDB/00070/2020 UIDB/50006/2020 PhD grant SFRH/BD/ 111576/2015 funded by the European Social Fund of the European Union and national funds FCT/MCTES Portuguese National NMR Network (PTNMR), supported by FCT funds as the NMR spectrometer used is part of PTNMR and partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL, and the FCT through PIDDAC) |
Título da revista, periódico, livro ou evento: | Molecules | Volume: | 26 | Número: | 16 | Resumo: | This paper reports the first metabolomics study of the impact of new chelates Pt2Spm and Pd2Spm (Spm = Spermine) on human osteosarcoma cellular metabolism, compared to the conventional platinum drugs cisplatin and oxaliplatin, in order to investigate the effects of different metal centers and ligands. Nuclear Magnetic Resonance metabolomics was used to identify meaningful metabolite variations in polar cell extracts collected during exposure to each of the four chelates. Cisplatin and oxaliplatin induced similar metabolic fingerprints of changing metabolite levels (affecting many amino acids, organic acids, nucleotides, choline compounds and other compounds), thus suggesting similar mechanisms of action. For these platinum drugs, a consistent uptake of amino acids is noted, along with an increase in nucleotides and derivatives, namely involved in glycosylation pathways. The Spm chelates elicit a markedly distinct metabolic signature, where inverse features are observed particularly for amino acids and nucleotides. Furthermore, Pd2Spm prompts a weaker response from osteosarcoma cells as compared to its platinum analogue, which is interesting as the palladium chelate exhibits higher cytotoxicity. Putative suggestions are discussed as to the affected cellular pathways and the origins of the distinct responses. This work demonstrates the value of untargeted metabolomics in measuring the response of cancer cells to either conventional or potential new drugs, seeking further understanding (or possible markers) of drug performance at the molecular level. | URI: | https://hdl.handle.net/10316/105266 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules26164805 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Response-of-osteosarcoma-cell-metabolism-to-platinum-and-palladium-chelates-as-potential-new-drugsMolecules.pdf | 4.16 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
9
Visto em 7/out/2024
Citações WEB OF SCIENCETM
6
Visto em 2/fev/2024
Visualizações de página
89
Visto em 15/out/2024
Downloads
72
Visto em 15/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons