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Title: Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
Authors: Petit, Robert Gironés
Cano, Amanda 
Ortiz, Alba
Espina, Marta
Prat, Josefina
Muñoz, Montserrat
Severino, Patrícia
Souto, Eliana B. 
Garcia, Maria L. 
Pujol, Montserrat
Sánchez-López, Elena
Keywords: skin inflammatory diseases; psoriasis; psoriasis versus atopic dermatitis; biodegradable nanoparticles; microneedles; clinical trials
Issue Date: 7-May-2021
Publisher: MDPI AG
Project: UIDB/04469/2020 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 22
Issue: 9
Abstract: Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.
ISSN: 1422-0067
DOI: 10.3390/ijms22094983
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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