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Title: The Neurophysiological Impact of Subacute Stroke: Changes in Cortical Oscillations Evoked by Bimanual Finger Movement
Authors: Dionísio, Ana 
Gouveia, Rita 
Castelhano, João 
Duarte, Isabel 
Santo, Gustavo C.
Sargento-Freitas, João 
Branco, Miguel Castelo 
Issue Date: 2022
Publisher: Hindawi Limited
Project: Prémio FLAD Life Sciences 2020 
COMPETE (DSAIPA/ DS/0041/2020) 
BIGDATIMAGE (CENTRO-01-0145-FEDER-000016) financed by Centro 2020 FEDER, COMPETE, and PAC–MEDPERSYST (POCI-01-0145-FEDER-016428) 
Serial title, monograph or event: Stroke Research and Treatment
Volume: 2022
Abstract: Introduction. To design more effective interventions, such as neurostimulation, for stroke rehabilitation, there is a need to understand early physiological changes that take place that may be relevant for clinical monitoring. We aimed to study changes in neurophysiology following recent ischemic stroke, both at rest and with motor planning and execution. Materials and Methods. We included 10 poststroke patients, between 7 and 10 days after stroke, and 20 age-matched controls to assess changes in cortical motor output via transcranial magnetic stimulation and in dynamics of oscillations, as recorded using electroencephalography (EEG). Results. We found significant differences in cortical oscillatory patterns comparing stroke patients with healthy participants, particularly in the beta rhythm during motor planning (p = 0:011) and execution (p = 0:004) of a complex movement with fingers from both hands simultaneously. Discussion. The stroke lesion induced a decrease in event-related desynchronization in patients, in comparison to controls, providing evidence for decreased disinhibition. Conclusions. After a stroke lesion, the dynamics of cortical oscillations is changed, with an increasing neural beta synchronization in the course of motor preparation and performance of complex bimanual finger tasks. The observed patterns may provide a potential functional measure that could be used to monitor and design interventional approaches in subacute stages.
ISSN: 2090-8105
DOI: 10.1155/2022/9772147
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais
FCTUC Física - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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