Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/103451
Title: Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves
Authors: Moreira, Patrícia 
Sousa, Fábio Jesus 
Matos, Patrícia 
Brites, Gonçalo Sousa 
Gonçalves, Maria José 
Cavaleiro, Carlos 
Figueirinha, Artur 
Salgueiro, Lígia 
Batista, Maria Teresa 
Branco, Pedro Costa
Cruz, Maria Teresa 
Pereira, Cláudia Fragão 
Keywords: Eucalyptus globulus; essential oil; aqueous phenolic extract; skin health; cytotoxicity; inflammation; aging; allergy; hyperpigmentation
Issue Date: 3-Mar-2022
Publisher: MDPI
Project: Project inpactus—innovative products and technologies from eucalyptus, Project N.º 21874 (POCI-01-0247-FEDER-021874), funded by Portugal 2020 through the European Regional Development Fund (ERDF) in the frame of COMPETE 2020 nº246/AXIS II/2017 
UIDB/04539/2020 
UIDP/04539/2020 
Serial title, monograph or event: Pharmaceutics
Volume: 14
Issue: 3
Abstract: Eucalyptus globulus is planted extensively for pulp, paper and wood production. Although bioactive compounds obtained from its biomass are used as cosmetics ingredients, the skin effects were not yet fully explored. In order to fill this gap, this work aimed to study the protective effect against skin damage provided by the essential oil (EO) obtained from the hydrodistillation of Eucalyptus globulus leaves, and by an extract obtained from the hydrodistillation residual water (HRW). The major compound identified in the EO was 1,8-Cineole, and the phenolic acids in the HRW included gallic acid as the main phenolic constituent. Moreover, non-toxic EO and HRW concentrations were shown to have anti-aging skin effects in vitro, decreasing age-related senescence markers, namely β-galactosidase and matrix metalloproteinases activation, as well as collagen type 1 upregulation. In addition, EO and HRW were found to exhibit depigmenting effects by inhibiting tyrosinase and melanin production, along with potent anti-inflammatory properties. Furthermore, the absence of skin irritation and sensitization in cells exposed to EO and HRW revealed the safety of both extracts for topical use. Taken together, these results highlight the beneficial effects of extracts obtained from Eucalyptus globulus biomass for skin aesthetic and health purposes, which should be explored deeply for the prediction of future pharmaceutical and dermocosmetics industrial applications.
URI: http://hdl.handle.net/10316/103451
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics14030561
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
I&D CIEPQPF - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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