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https://hdl.handle.net/10316/102608
Title: | Differential regulation of the heat shock factor 1 and DAF-16 by neuronal nhl-1 in the nematode C. elegans | Authors: | Volovik, Yuli Moll, Lorna Marques, Filipa Carvalhal Maman, Moria Bejerano-Sagie, Michal Cohen, Ehud |
Issue Date: | 24-Dec-2014 | Serial title, monograph or event: | Cell Reports | Volume: | 9 | Issue: | 6 | Abstract: | In the nematode Caenorhabditis elegans, insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) reduction hyperactivates the transcription factors DAF-16 and heat shock factor 1 (HSF-1), creating long-lived, stress-resistant worms that are protected from proteotoxicity. How DAF-16 executes its distinct functions in response to IIS reduction is largely obscure. Here, we report that NHL-1, a member of the TRIM-NHL protein family, acts in chemosensory neurons to promote stress resistance in distal tissues by DAF-16 activation but is dispensable for the activation of HSF-1. The expression of nhl-1 is regulated by the IIS, defining a neuronal regulatory circuit that controls the organismal stress response. The knockdown of nhl-1 protects nematodes that express the Alzheimer-disease-associated Aβ peptide from proteotoxicity but has no effect on lifespan. Our findings indicate that DAF-16- and HSF-1-regulated heat-responsive mechanisms are differentially controlled by neurons and show that one neuronal protein can be involved in the activation of different stress responses in remote tissues. | URI: | https://hdl.handle.net/10316/102608 | ISSN: | 22111247 | DOI: | 10.1016/j.celrep.2014.11.028 | Rights: | openAccess |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais |
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