Please use this identifier to cite or link to this item:
Title: Extracellular Vesicles as Platforms for Therapeutic MicroRNA delivery
Authors: Abreu, Ricardo Cerqueira de 
Orientador: Ferreira, Lino da Silva
Fernandes, Hugo Agostinho Machado
Martins, Paula da Costa
Issue Date: 21-Feb-2022
Project: POCI-01-0145-FEDER-029919
info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/BTM-SAL/29919/2017/PT/Exo-Heart: cardiac protection and regeneration mediated by systemic administration of targeted exosomes 
Dutch Heart Foundation Dr. Dekker Established Investigator Grant 2015T066 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/QUI/00313/2019/PT/Coimbra Chemistry Center 
info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/DTP-FTO/2784/2014/PT/Unraveling the Rules of Passive Permeation Through the Blood-Brain Barrier 
info:eu-repo/grantAgreement/EC/H2020/952266/EU/RESEarch for healThy AGEING 
info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH/BD/129317/2017/PT/Boosting cardiac protection and regeneration through exosomal biomodulation 
info:eu-repo/grantAgreement/null/null/COVID/BD/152146/2021/null/Boosting cardiac protection and regeneration through exosomal biomodulation 
Place of publication or event: Coimbra
Abstract: Life does not exist in a vacuum. In other words, for there to be life, there had to be life. Historically, that notion may be challenged by life’s very origins. In the modern age, life may now be synthetized. Nevertheless, enshrined in the tenets of cell theory, this idea offers some solace in the face of the cosmic inconsequence that underlies existence. Life does not exist in a vacuum; therefore, life is never alone. From unicellular beings to complex organisms, life exists and thrives in tandem with itself. We could lose ourselves in the complexities of Archaea processes or the nuance of Bacteria interaction. A bit closer to home perhaps, we might ponder on the necessity of communities and hierarchies in plants and animals. The idea of family. All of that is brought together in a single aspect. Communication. All of life needs something to “speak” to. In fact, it depends on it. Exchange of molecular signals, establishment of functional populations, food chains, interpersonal relationships all depend on effective communication. And life has devised a number of unique forms of communication, including the subject of this thesis: extracellular vesicles. If life had a purpose, extrinsic to its self-perpetuating nature, would it then not be to be understood? We may never know, but in research we make use of the tools at our disposal to decode life’s speech and understand it. Whether life craves communication and understanding, or that is our observer’s bias, once a question is posed, what choice do we have but to answer it?
Description: Tese de Doutoramento em Biologia Experimental e Biomedicina, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra
Rights: embargoedAccess
Appears in Collections:UC - Teses de Doutoramento
IIIUC - Teses de Doutoramento

Files in This Item:
File Description SizeFormat
PhD Thesis_RA final.pdf4.89 MBAdobe PDFView/Open
Show full item record

Page view(s)

checked on May 15, 2024


checked on May 15, 2024

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.