Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/100415
DC FieldValueLanguage
dc.contributor.advisorFerreira, Lino da Silva-
dc.contributor.advisorFernandes, Hugo Agostinho Machado-
dc.contributor.advisorMartins, Paula da Costa-
dc.contributor.authorAbreu, Ricardo Cerqueira de-
dc.date.accessioned2022-06-17T10:05:42Z-
dc.date.available2022-06-17T10:05:42Z-
dc.date.issued2022-02-21-
dc.date.submitted2022-02-21-
dc.identifier.urihttp://hdl.handle.net/10316/100415-
dc.descriptionTese de Doutoramento em Biologia Experimental e Biomedicina, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbrapt
dc.description.abstractLife does not exist in a vacuum. In other words, for there to be life, there had to be life. Historically, that notion may be challenged by life’s very origins. In the modern age, life may now be synthetized. Nevertheless, enshrined in the tenets of cell theory, this idea offers some solace in the face of the cosmic inconsequence that underlies existence. Life does not exist in a vacuum; therefore, life is never alone. From unicellular beings to complex organisms, life exists and thrives in tandem with itself. We could lose ourselves in the complexities of Archaea processes or the nuance of Bacteria interaction. A bit closer to home perhaps, we might ponder on the necessity of communities and hierarchies in plants and animals. The idea of family. All of that is brought together in a single aspect. Communication. All of life needs something to “speak” to. In fact, it depends on it. Exchange of molecular signals, establishment of functional populations, food chains, interpersonal relationships all depend on effective communication. And life has devised a number of unique forms of communication, including the subject of this thesis: extracellular vesicles. If life had a purpose, extrinsic to its self-perpetuating nature, would it then not be to be understood? We may never know, but in research we make use of the tools at our disposal to decode life’s speech and understand it. Whether life craves communication and understanding, or that is our observer’s bias, once a question is posed, what choice do we have but to answer it?pt
dc.language.isoengpt
dc.relation007630UID/QUI/00313/2019pt
dc.relationPT2020_PTDC_DTP-FTO_2784_2014pt
dc.relationPOCI-01-0145-FEDER-029919pt
dc.relationinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/BTM-SAL/29919/2017/PT/Exo-Heart: cardiac protection and regeneration mediated by systemic administration of targeted exosomespt
dc.relationDutch Heart Foundation Dr. Dekker Established Investigator Grant 2015T066pt
dc.relationEAPA_791/2018 - NEUROATLANTICpt
dc.relationgrant agreement No952266 (Project RESETageing)pt
dc.relationSFRH/BD/129317/2017pt
dc.relationCOVID/BD/152146/2021pt
dc.rightsembargoedAccesspt
dc.titleExtracellular Vesicles as Platforms for Therapeutic MicroRNA deliverypt
dc.typedoctoralThesispt
degois.publication.locationCoimbrapt
dc.peerreviewedyes-
dc.date.embargo2023-02-21*
dc.identifier.tid101688300pt
dc.subject.fosCiências Biológicaspt
thesis.degree.disciplineID03019510-
thesis.degree.leveldoutor-
thesis.degree.nameDoutoramento em Biologia Experimental e Biomedicinapt
uc.rechabilitacaoestrangeirayespt
uc.date.periodoEmbargo365pt
item.grantfulltextembargo_20230221-
item.fulltextCom Texto completo-
item.openairetypedoctoralThesis-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.advisor.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.advisor.orcid0000-0001-8985-9302-
Appears in Collections:IIIUC - Teses de Doutoramento
UC - Teses de Doutoramento
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