Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/100415
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Ferreira, Lino da Silva | - |
dc.contributor.advisor | Fernandes, Hugo Agostinho Machado | - |
dc.contributor.advisor | Martins, Paula da Costa | - |
dc.contributor.author | Abreu, Ricardo Cerqueira de | - |
dc.date.accessioned | 2022-06-17T10:05:42Z | - |
dc.date.available | 2022-06-17T10:05:42Z | - |
dc.date.issued | 2022-02-21 | - |
dc.date.submitted | 2022-02-21 | - |
dc.identifier.uri | https://hdl.handle.net/10316/100415 | - |
dc.description | Tese de Doutoramento em Biologia Experimental e Biomedicina, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra | pt |
dc.description.abstract | Life does not exist in a vacuum. In other words, for there to be life, there had to be life. Historically, that notion may be challenged by life’s very origins. In the modern age, life may now be synthetized. Nevertheless, enshrined in the tenets of cell theory, this idea offers some solace in the face of the cosmic inconsequence that underlies existence. Life does not exist in a vacuum; therefore, life is never alone. From unicellular beings to complex organisms, life exists and thrives in tandem with itself. We could lose ourselves in the complexities of Archaea processes or the nuance of Bacteria interaction. A bit closer to home perhaps, we might ponder on the necessity of communities and hierarchies in plants and animals. The idea of family. All of that is brought together in a single aspect. Communication. All of life needs something to “speak” to. In fact, it depends on it. Exchange of molecular signals, establishment of functional populations, food chains, interpersonal relationships all depend on effective communication. And life has devised a number of unique forms of communication, including the subject of this thesis: extracellular vesicles. If life had a purpose, extrinsic to its self-perpetuating nature, would it then not be to be understood? We may never know, but in research we make use of the tools at our disposal to decode life’s speech and understand it. Whether life craves communication and understanding, or that is our observer’s bias, once a question is posed, what choice do we have but to answer it? | pt |
dc.description.sponsorship | This work was partially supported by the Portuguese ‘Fundação para a Ciência e a Tecnologia’ (FCT) through projects 007630UID/QUI/00313/2019, PT2020_PTDC_DTP-FTO_2784_2014, POCI-01-0145-FEDER-029919, co-funded by COMPETE2020-UE and CENTRO-01-0145-FEDER-000014 through ‘Programa Operacional Regional do Centro’ CENTRO2020; Project Exo-Heart (POCI-01-0145-FEDER-029919); Dutch Heart Foundation grant (NHS2015T066); Projects Inter-reg entitled: ‘Impulso de una red de I+i en química biológica para diagnóstico y tratamiento de enfermedades neurológicas’and EAPA_791/2018 - NEUROATLANTIC entitled: ‘An Atlantic innovation platform on diagnosis and treatment of neuro-logical diseases and aging’ and European Union’s Horizon 2020 research and innovation program under grant agreement No952266 (Project RESETageing). Ricardo Abreu was supported by FCT through the fellowships SFRH/BD/129317/2017 and COVID/BD/152146/2021. | pt |
dc.language.iso | eng | pt |
dc.relation | POCI-01-0145-FEDER-029919 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/BTM-SAL/29919/2017/PT/Exo-Heart: cardiac protection and regeneration mediated by systemic administration of targeted exosomes | pt |
dc.relation | Dutch Heart Foundation Dr. Dekker Established Investigator Grant 2015T066 | pt |
dc.relation | EAPA_791/2018 - NEUROATLANTIC | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/QUI/00313/2019/PT/Coimbra Chemistry Center | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/DTP-FTO/2784/2014/PT/Unraveling the Rules of Passive Permeation Through the Blood-Brain Barrier | pt |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/952266/EU/RESEarch for healThy AGEING | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH/BD/129317/2017/PT/Boosting cardiac protection and regeneration through exosomal biomodulation | pt |
dc.relation | info:eu-repo/grantAgreement/null/null/COVID/BD/152146/2021/null/Boosting cardiac protection and regeneration through exosomal biomodulation | pt |
dc.rights | embargoedAccess | pt |
dc.title | Extracellular Vesicles as Platforms for Therapeutic MicroRNA delivery | pt |
dc.type | doctoralThesis | pt |
degois.publication.location | Coimbra | pt |
dc.peerreviewed | yes | - |
dc.date.embargo | 2023-02-21 | * |
dc.identifier.tid | 101688300 | pt |
dc.subject.fos | Ciências Biológicas | pt |
thesis.degree.disciplineID | 03019510 | - |
thesis.degree.level | doutor | - |
thesis.degree.name | Doutoramento em Biologia Experimental e Biomedicina | pt |
uc.rechabilitacaoestrangeira | yes | pt |
uc.date.periodoEmbargo | 365 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | doctoralThesis | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | RESEarch for healThy AGEING | - |
crisitem.advisor.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.advisor.orcid | 0000-0001-8985-9302 | - |
crisitem.advisor.orcid | 0000-0002-4574-7648 | - |
Appears in Collections: | UC - Teses de Doutoramento IIIUC - Teses de Doutoramento |
Files in This Item:
File | Description | Size | Format | |
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PhD Thesis_RA final.pdf | 4.89 MB | Adobe PDF | View/Open |
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