This work was supported by the National Institute of General Medical Sciences (NIGMS) under the COBRE Award Number P20GM109096 (EC), and the Arkansas Biosciences Institute/Arkansas Children's Research Institute (EC/SR), through the Discovery Acceleration Initiative/ Project Planning Grants and bridging funds as well as the UAMS College of Medicine (COM) Research Scholar Pilot Grant Awards in Child Health (EC). Funds were obtained also by the European Regional Development Fund, through the Centro 2020 Regional Operational Programme Healthy Aging 2020-CENTRO-01-0145-FEDER-000012 and through the COMPETE 2020-Operational Programme for Competitiveness and Internalization and Fundaç˜ao para a Ciˆencia e a Tecnologia, projects POCI-01-0145-FEDER-007440, UIDB/04539/2020, UIDP/ 04539/2020, and SRFH/BD/144199/2019 (DS). EB was partly funded by NIH/NIGMS UL1 TR003107 and KL2 TR003108 and USDA/ARS 6062-51000-012-06-S. AES was funded by a post-doctoral fellowship from the Danish Diabetes Academy, funded by the Novo Nordisk Foundation NNF17SA0031406.