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This research was funded by FCT—Fundação para a Ciência e a Tecnologia, thorough the grants PTDC/QEQ-MED/7042/2014, UID/DTP/04138/2019 and the PhD grant SFRH/BD/104441/2014 (R.A.G.) and was also supported by the European Structural & Investment Funds through the COMPETE Programme under grant LISBOA-01-0145-FEDER-016405 (SAICTPAC/0019/2015). J.A.R.S. is also thankful for the funding from the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under the projects CENTRO-01-0247-FEDER-003269 (Drugs2CAD) and CENTRO-01-0145-FEDER-000012 (HealthyAging2020) and through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization.