Research was funded by NIH (5R01GM078465) and the Empire State Stem Cell Fund through New York State Department of Health (NYSTEM: C024176) to I.R.L.; by European Structural and Investment Funds (ESIF), under Lisbon Portugal Regional Operational Programme and National Funds through Foundation for Science and Technology (FCT) under project POCI-01-0145- FEDER-016385 to P.P.-O´ . A.G.F. and T.P.R. were supported by FCT (SFRH/BD/64715/2009 and SFRH/BPD/80588/2011, respectively); D.-F.L. by NIH Pathway to Independence Award (K99CA181496); and C.-F.P. by Charles H. Revson Senior Fellowship in Biomedical Science (New York) and FCT investigator IF/00646/2015. P.P.-O´ . was recipient of an invited scientist grant by Institut Pasteur, Paris, France.