The present work was financed by Portuguese national funds via Fundação para a Ciência e a Tecnologia (FCT), under the projects EXPL/NEU-NMC/0671/ 2012 and PTDC/NEU-NMC/3567/2014 granted to R.J.R.; by Alzheimer Association under the project NIRG-15-361884 granted to R.J.R.; and by Santa Casa da Misericórdia and Prémio Maratona da Saúde granted to R.A.C. This work was also financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000008:BrainHealth2020, and through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization and Portuguese national funds via FCT, under the project POCI-01-0145- FEDER-007440. A.P.S. was recipient of a postdoctoral fellowship (SFRH/BPD/ 91683/2012); J.M.M. was supported by a postdoctoral fellowship (SFRH/BPD/ 107903/2015). J.L. acknowledges financial support from the Spanish Ministry of Economy and Competitiveness, through the “Severo Ochoa” Programme for Centres of Excellence in R&D (SEV—2013-0317