Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/96864
DC Field | Value | Language |
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dc.contributor.author | Queiroz, Marcelo | - |
dc.contributor.author | Leandro, Adriana | - |
dc.contributor.author | Azul, Lara | - |
dc.contributor.author | Figueirinha, Artur | - |
dc.contributor.author | Seiça, Raquel | - |
dc.contributor.author | Sena, Cristina M. | - |
dc.date.accessioned | 2021-12-30T15:41:26Z | - |
dc.date.accessioned | 2021-12-30T15:43:33Z | - |
dc.date.available | 2021-12-30T15:41:26Z | - |
dc.date.available | 2021-12-30T15:43:33Z | - |
dc.date.issued | 2021-12-20 | - |
dc.identifier.issn | 1422-0067 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/96864 | - |
dc.description.abstract | We investigated the effects of luteolin on metabolism, vascular reactivity, and perivascular adipose tissue (PVAT) in nonobese type 2 diabetes mellitus animal model, Goto-Kakizaki (GK) rats. Methods: Wistar and GK rats were divided in two groups: (1) control groups treated with vehicle; (2) groups treated with luteolin (10 mg/kg/day, for 2 months). Several metabolic parameters such as adiposity index, lipid profile, fasting glucose levels, glucose and insulin tolerance tests were determined. Endothelial function and contraction studies were performed in aortas with (PVAT+) or without (PVAT−) periaortic adipose tissue. We also studied vascular oxidative stress, glycation and assessed CRP, CCL2, and nitrotyrosine levels in PVAT. Results: Endothelial function was impaired in diabetic GK rats (47% (GK − PVAT) and 65% (GK + PVAT) inhibition of maximal endothelial dependent relaxation) and significantly improved by luteolin treatment (29% (GK − PVAT) and 22% (GK + PVAT) inhibition of maximal endothelial dependent relaxation, p < 0.01). Vascular oxidative stress and advanced glycation end-products’ levels were increased in aortic rings (~2-fold, p < 0.05) of diabetic rats and significantly improved by luteolin treatment (to levels not significantly different from controls). Periaortic adipose tissue anti-contractile action was significantly rescued with luteolin administration (p < 0.001). In addition, luteolin treatment significantly recovered proinflammatory and pro-oxidant PVAT phenotype, and improved systemic and metabolic parameters in GK rats. Conclusions: Luteolin ameliorates endothelial dysfunction in type 2 diabetes and exhibits therapeutic potential for the treatment of vascular complications associated with type 2 diabetes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | POCI-01-0145-FEDER-007440 | pt |
dc.relation | UID/NEU/04539/2019 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDB/50006/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Endothelial dysfunction | pt |
dc.subject | Inflammation | pt |
dc.subject.mesh | Luteolin | pt |
dc.subject.mesh | Oxidative stress | pt |
dc.subject.mesh | Type 2 diabetes | pt |
dc.title | Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats | pt |
dc.type | article | - |
degois.publication.firstPage | 13671 | pt |
degois.publication.issue | 24 | pt |
degois.publication.title | International Journal of Molecular Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ijms222413671 | pt |
degois.publication.volume | 22 | pt |
dc.date.embargo | 2021-12-20 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | MARE - Marine and Environmental Sciences Centre | - |
crisitem.author.orcid | 0000-0002-8791-6569 | - |
crisitem.author.orcid | 0000-0003-3064-5718 | - |
crisitem.author.orcid | 0000-0002-8378-0895 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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ijms-22-13671.pdf | 2.74 MB | Adobe PDF | View/Open |
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