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Title: | Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis | Authors: | Morganti, Claudia Missiroli, Sonia Lebiedzinska-Arciszewska, Magdalena Ferroni, Letizia Morganti, Lucia Perrone, Mariasole Ramaccini, Daniela Occhionorelli, Savino Zavan, Barbara Wieckowski, Mariusz R. Giorgi, Carlotta |
Issue Date: | Aug-2019 | Publisher: | Springer Nature | Project: | MarieSkłodowska-Curie Grant Agreement No. 722619 (FOIE GRAS) MarieSkłodowska-Curie Grant Agreement No. 734719 (mtFOIE GRAS) Italian Association for Cancer Research, the Italian Ministry of Health, and by Cariplo grant |
Serial title, monograph or event: | International Journal of Obesity | Volume: | 43 | Issue: | 5 | Abstract: | Obesity is a complex disease characterized by the accumulation of excess body fat, which is caused by an increase in adipose cell size and number. The major source of adipocytes comes from mesenchymal stem cells (MSCs), although their roles in obesity remain unclear. An understanding of the mechanisms, regulation, and outcomes of adipogenesis is crucial for the development of new treatments for obesity-related diseases. Recently an unexpected role for the tumor suppressor promyelocytic leukemia protein (PML) in hematopoietic stem cell biology and metabolism regulation has come to light, but its role in MSC biology remains unknown. Here, we investigated the molecular pathway underlying the role of PML in the control of adipogenic MSC differentiation. | URI: | https://hdl.handle.net/10316/95091 | ISSN: | 0307-0565 1476-5497 |
DOI: | 10.1038/s41366-018-0167-1 | Rights: | embargoedAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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PKCb_Accepted.pdf | 13.36 MB | Adobe PDF | View/Open |
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