Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/95089
Title: Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases
Authors: Marques-Aleixo, Inês 
Beleza, Jorge
Sampaio, Arnaldina
Stevanović, Jelena
Coxito, Pedro 
Gonçalves, Inês
Ascensão, António 
Magalhães, José 
Keywords: BDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscle
Issue Date: 2021
Project: Marie Skłodowska-Curie (FOIE GRAS) No.722619 
Marie Skłodowska-Curie (mtFOIE GRAS) No.734719 
FCT/UID/DTP/00617/2019 
POCI-01-0145-FEDER-016690-PTDC/DTP-702DES/7087/2014 
POCI-01-0145-FEDER-016657–PTDC/DTP-DES/1082/2014 
JB SFRH/BD/129645/2017. 
Serial title, monograph or event: Antioxidants & Redox Signaling
Volume: 34
Issue: 8
Abstract: Significance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. On the contrary, absent of detrimental side effects but growing merits, regular physical exercise (PE) has been considered a prone pleiotropic nonpharmacological alternative able to modulate brain structure and function, thereby stimulating a healthier and "fitness" neurological phenotype. Future Directions: This review summarizes the state of the art of some peripheral and central-related mechanisms that underlie the impact of PE on brain plasticity as well as its relevance for the prevention and/or treatment of NDDs. Nevertheless, further studies are needed to better clarify the molecular signaling pathways associated with muscle contractions-related myokines release and its plausible positive effects in the brain. In addition, particular focus of research should address the role of PE in the modulation of mitochondrial metabolism and oxidative stress in the context of NDDs.
URI: https://hdl.handle.net/10316/95089
ISSN: 1523-0864
1557-7716
DOI: 10.1089/ars.2020.8075
Rights: embargoedAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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