Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/95081
Title: The color of fat and its central role in the development and progression of metabolic diseases
Authors: Gaggini, Melania
Carli, Fabrizia
Gastaldelli, Amalia
Keywords: NAFLD; brown adipose tissue; insulin resistance; lipid metabolism
Issue Date: 25-Sep-2017
Project: info:eu-repo/grantAgreement/EC/H2020/634413/EU/Elucidating Pathways of Steatohepatitis 
info:eu-repo/grantAgreement/EC/H2020/722619/EU/Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease 
info:eu-repo/grantAgreement/EC/FP7/609475/EU/EURO-MEDITERRANEAN Cooperation through ERANET joint activities and beyond 
Serial title, monograph or event: Hormone Molecular Biology and Clinical Investigation
Volume: 31
Issue: 1
Abstract: Excess caloric intake does not always translate to an expansion of the subcutaneous adipose tissue (SAT) and increase in fat mass. It is now recognized that adipocyte type (white, WAT, or brown, BAT), size (large vs. small) and metabolism are important factors for the development of cardiometabolic diseases. When the subcutaneous adipose tissue is not able to expand in response to increased energy intake the excess substrate is stored as visceral adipose tissue or as ectopic fat in tissues as muscle, liver and pancreas. Moreover, adipocytes become dysfunctional (adiposopathy, or sick fat), adipokines secretion is increased, fat accumulates in ectopic sites like muscle and liver and alters insulin signaling, increasing the demand for insulin secretion. Thus, there are some subjects that despite having normal weight have the metabolic characteristics of the obese (NWMO), while some obese expand their SAT and remain metabolically healthy (MHO). In this paper we have reviewed the recent findings that relate the metabolism of adipose tissue and its composition to metabolic diseases. In particular, we have discussed the possible role of dysfunctional adipocytes and adipose tissue resistance to the antilipolytic effect of insulin on the development of impaired glucose metabolism. Finally we have reviewed the possible role of BAT vs. WAT in the alteration of lipid and glucose metabolism and the recent studies that have tried to stimulate browning in human adipose tissue.
URI: https://hdl.handle.net/10316/95081
ISSN: 1868-1891
DOI: 10.1515/hmbci-2017-0060
Rights: embargoedAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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