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Title: The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective
Authors: Simoes, Ines C M
Morciano, Giampaolo
Lebiedzinska-Arciszewska, Magdalena
Aguiari, Gianluca
Pinton, Paolo
Potes, Yaiza
Wieckowski, Mariusz R. 
Keywords: Cancer; Endoplasmic reticulum; Mitochondria; Mitochondria-associated membranes (MAM); Oncogenes; Oncosuppressors
Issue Date: Oct-2020
Project: Polish National Science Centre grant UMO- 2018/29/B/NZ1/00589 
Marie Skłodowska-Curie Grant Agreement No. 722619 (FOIE GRAS) 
Marie Skłodowska-Curie Grant Agreement No. 734719 (mtFOIE GRAS) 
Polish National Science Centre grant (UMO-2015/17/D/NZ1/00030) 
Italian Association for Cancer Research (AIRC, IG-23670), 
Telethon (GGP11139B) 
Progetti di Rilevante Interesse Nazionale (PRIN, 2017 E5L5P3) 
Serial title, monograph or event: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume: 1866
Issue: 10
Abstract: Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca2+ flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. In the present review, we summarize the current understanding of basic MAM biology, composition and function and discuss the possible role of MAM-resident oncogenes and tumor suppressors.
ISSN: 09254439
DOI: 10.1016/j.bbadis.2020.165834
Rights: embargoedAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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