Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/92842
DC Field | Value | Language |
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dc.contributor.author | Gaspar, M. C. | - |
dc.contributor.author | Sousa, João José Martins Simões | - |
dc.contributor.author | Pais, Alberto António Caria Canelas | - |
dc.contributor.author | Cardoso, O. M. | - |
dc.contributor.author | Murtinho, Dina Maria Bairrada | - |
dc.contributor.author | Serra, M. E. S. | - |
dc.contributor.author | Tewes, F. | - |
dc.contributor.author | Olivier, J.-C. | - |
dc.date.accessioned | 2021-02-02T10:33:41Z | - |
dc.date.available | 2021-02-02T10:33:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 09396411 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/92842 | - |
dc.description.abstract | The aim of this work was the development of innovative levofloxacin-loaded swellable microspheres (MS) for the dry aerosol therapy of pulmonary chronicPseudomonas aeruginosainfections in Cystic Fibrosis patients. In a first step, a factorial design was applied to optimize formulations of chitosan-based MS with glutaraldehyde as crosslinker. After optimization, other crosslinkers (genipin, glutaric acid and glyceraldehyde) were tested. Analyses of MS included aerodynamic and swelling properties, morphology, drug loading, thermal and chemical characteristics,in vitroantibacterial activity and drug release studies. The prepared MS presented a drug content ranging from 39.8% to 50.8% of levofloxacin in an amorphous or dispersed state, antibacterial activity and fast release profiles. The highest degree of swelling was obtained for MS crosslinked with glutaric acid and genipin. These formulations also presented satisfactory aerodynamic properties, making them a promising alternative, in dry-powder inhalers, to levofloxacin solution for inhalation. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH/BD/80307/2011/PT/PULMONARY TARGETING AND BIOPHARMACEUTICAL EVALUATIONS OF ANTI-INFECTIVE DRUGS ADMINISTERED AS INNOVATIVE MICROSPHERE AEROSOLS | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Aerosol; Chitosan; Crosslinking agents; Cystic Fibrosis; Experimental design; Levofloxacin; Lung delivery; Microspheres | pt |
dc.subject.mesh | Anti-Bacterial Agents | pt |
dc.subject.mesh | Chitosan | pt |
dc.subject.mesh | Cross-Linking Reagents | pt |
dc.subject.mesh | Cystic Fibrosis | pt |
dc.subject.mesh | Drug Carriers | pt |
dc.subject.mesh | Drug Liberation | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Levofloxacin | pt |
dc.subject.mesh | Microspheres | pt |
dc.subject.mesh | Particle Size | pt |
dc.subject.mesh | Powder Diffraction | pt |
dc.subject.mesh | Pseudomonas Infections | pt |
dc.subject.mesh | Pseudomonas aeruginosa | pt |
dc.subject.mesh | Respiratory Therapy | pt |
dc.subject.mesh | Spectroscopy, Fourier Transform Infrared | pt |
dc.subject.mesh | Surface Properties | pt |
dc.subject.mesh | Technology, Pharmaceutical | pt |
dc.title | Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy | pt |
dc.type | article | - |
degois.publication.firstPage | 65-75 | pt |
degois.publication.lastPage | 75 | pt |
degois.publication.title | European Journal of Pharmaceutics and Biopharmaceutics | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0939641115002994 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.ejpb.2015.07.010 | pt |
degois.publication.volume | 96 | pt |
dc.date.embargo | 2015-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CIEPQPF – Chemical Process Engineering and Forest Products Research Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-5584-6324 | - |
crisitem.author.orcid | 0000-0001-9718-8035 | - |
crisitem.author.orcid | 0000-0002-6725-6460 | - |
crisitem.author.orcid | 0000-0002-8902-0213 | - |
crisitem.author.orcid | 0000-0002-1391-9855 | - |
crisitem.author.orcid | 0000-0002-4562-7072 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Gaspar et al, 2015.pdf | 1.31 MB | Adobe PDF | View/Open |
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