Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/90926
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alves, Cláudia | - |
dc.contributor.author | Grosso, Carla | - |
dc.contributor.author | Barrulas, Pedro | - |
dc.contributor.author | Paixão, José A. | - |
dc.contributor.author | Cardoso, Ana L. | - |
dc.contributor.author | Burke, Anthony J. | - |
dc.contributor.author | Lemos, Américo | - |
dc.contributor.author | Melo, Teresa M. V. D. Pinho e | - |
dc.date.accessioned | 2020-09-10T15:38:01Z | - |
dc.date.available | 2020-09-10T15:38:01Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0936-5214 | pt |
dc.identifier.issn | 1437-2096 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/90926 | - |
dc.description.abstract | A successful one-pot methodology for the synthesis of chiral 2-tetrazolyl-2H-azirines has been established, resorting to organocatalysis. The protocol involves the in situ tosylation of β-ketoxime-1H-tetrazoles followed by the Neber reaction, in the presence of chiral organocatalysts. Among the organocatalysts studied a novel thiourea catalyst derived from 6β-aminopenicillanic acid afforded excellent enantioselectivities. | pt |
dc.language.iso | eng | pt |
dc.publisher | Georg Thieme Verlag | pt |
dc.relation | UID/QUI/00313/2019 | pt |
dc.relation | SFRH/BD/130198/2017 | pt |
dc.relation | PD/BD/143159/2019 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | 2H-azirines | pt |
dc.subject | Asymmetric Neber reaction | pt |
dc.subject | Organocatalysis | pt |
dc.subject | Tetrazoles | pt |
dc.subject | Thiourea | pt |
dc.subject | 6β-aminopenicillanic acid | pt |
dc.title | Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines | pt |
dc.type | article | - |
degois.publication.firstPage | 1 | pt |
degois.publication.lastPage | 6 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Synlett | pt |
dc.relation.publisherversion | https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1691533 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1055/s-0039-1691533 | pt |
degois.publication.volume | 31 | pt |
dc.date.embargo | 2020-01-01 | * |
uc.date.periodoEmbargo | 365 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CFisUC – Center for Physics of the University of Coimbra | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-4634-7395 | - |
crisitem.author.orcid | 0000-0003-0551-7255 | - |
crisitem.author.orcid | 0000-0001-9588-4555 | - |
crisitem.author.orcid | 0000-0003-3256-4954 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Alves2020Synlett.pdf | 1.94 MB | Adobe PDF | View/Open |
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