Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/90813
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Mendes, Maria | - |
dc.contributor.author | Cova, Tânia | - |
dc.contributor.author | Basso, João | - |
dc.contributor.author | Ramos, M. Luísa | - |
dc.contributor.author | Vitorino, Rui | - |
dc.contributor.author | Sousa, João | - |
dc.contributor.author | Pais, Alberto | - |
dc.contributor.author | Vitorino, Carla | - |
dc.date.accessioned | 2020-09-08T15:30:22Z | - |
dc.date.available | 2020-09-08T15:30:22Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 01677322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/90813 | - |
dc.description.abstract | The main bottleneck of glioblastoma still relies on the existence of the blood brain-blood brain tumor dual barrier, along with the lack of therapy specificity. The present work deals with the question of whether (and how) different targeting hyaluronic acid (HA)-peptide [c(RGDfK) and/or H7K(R2)2] moieties hierarchically interact with each other, to ensure a unique entity with specificity to glioblastoma. A dual experimental-computational approach, encompassing nuclear magnetic resonance and molecular dynamics simulations is enclosed. Relevant contact patterns based on the identification of the stabilizing/destabilizing noncovalent interactions within the constructs are detailed. The synthesis pathway requires the HA-c(RGDfK)-H7k(R2)2 association hierarchy, stemming from the size and amino acid residue rearrangement, in the 1:1 M ratio, to obtain a stable conjugate ultimately able to interact with the tumor cell membrane. To our knowledge, the structural and mechanistic rationale for the formation of hybrid polymer-peptide constructs, including HA-c(RGDfK)-H7k(R2)2, for glioblastoma has not been addressed so far. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | POCI-01-0145-FEDER- 016648 | pt |
dc.relation | IF/00286/2015 | pt |
dc.relation | UID/BIM/04501/2019 | pt |
dc.relation | POCI-01-0145-FEDER-007628 | pt |
dc.relation | UID/IC/00051/2019 | pt |
dc.relation | SFRH/BD/133996/2017 | pt |
dc.relation | SFRH/BD/149138/2019 | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Hyaluronic acid | pt |
dc.subject | c(RGDfK) | pt |
dc.subject | H7k(R2)2 | pt |
dc.subject | Polymer-peptide conjugates | pt |
dc.subject | Glioblastoma | pt |
dc.title | Hierarchical design of hyaluronic acid-peptide constructs for glioblastoma targeting: Combining insights from NMR and molecular dynamics simulations | pt |
dc.type | article | - |
degois.publication.firstPage | 113774 | pt |
degois.publication.title | Journal of Molecular Liquids | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S016773222032331X | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.molliq.2020.113774 | pt |
degois.publication.volume | 315 | pt |
dc.date.embargo | 2020-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CNC. IBILI | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-3696-4517 | - |
crisitem.author.orcid | 0000-0002-2840-6091 | - |
crisitem.author.orcid | 0000-0002-6725-6460 | - |
crisitem.author.orcid | 0000-0003-3424-548X | - |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
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