Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/90792
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Rocha, Luis B | - |
dc.contributor.author | Soares, Helder T | - |
dc.contributor.author | Mendes, Maria Inês P | - |
dc.contributor.author | Cabrita, António | - |
dc.contributor.author | Schaberle, Fábio António | - |
dc.contributor.author | Moreira, Luís Guilherme da Silva Arnaut | - |
dc.date.accessioned | 2020-09-07T14:16:37Z | - |
dc.date.available | 2020-09-07T14:16:37Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0031-8655 | pt |
dc.identifier.issn | 1751-1097 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/90792 | - |
dc.description.abstract | Predicting the extent of necrosis in photodynamic therapy (PDT) is critical to ensure that the whole tumor is treated but vital structures, such as major blood vessels in the vicinity of the tumor, are spared. The models developed for clinical planning rely on empirical parameters that change with the nature of the photosensitizer and the target tissue. This work presents an in vivo study of the necrosis in the livers of rats due to PDT with a bacteriochlorin photosensitizer named redaporfin using both frontal illumination and interstitial illumination. Various doses of light at 750 nm were delivered 15 min postintravenous administration of redaporfin. Sharp boundaries between necrotic and healthy tissues were found. Frontal illumination allowed for the determination of the photodynamic threshold dose-1.5 × 1019 photons cm-3 -which means that the regions of the tissues exposed to more than 11 mm of ROS evolved to necrosis. Interstitial illumination produced a necrotic radius of 0.7 cm for a light dose of 100 J cm-1 and a redaporfin dose of 0.75 mg kg-1 . The experimental data obtained can be used to inform and improve clinical planning with frontal and interstitial illumination protocols. | pt |
dc.description.sponsorship | LaserLab Portugal (022124); LaserLab Europe 654148 | pt |
dc.language.iso | eng | pt |
dc.publisher | Wiley Online Library | pt |
dc.relation | UID/QUI/00313/2019 | pt |
dc.relation | PTDC/QEQ-MED/3521/2014 | pt |
dc.relation | POCI-01-0145-FEDER-027996 | pt |
dc.relation | SFRH/BD/119058/2016 | pt |
dc.relation | PD/BD/143129/2019 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt |
dc.title | Necrosis Depth and Photodynamic Threshold Dose with Redaporfin-PDT | pt |
dc.type | article | - |
degois.publication.firstPage | 692 | pt |
degois.publication.lastPage | 698 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | Photochemistry and Photobiology | pt |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1111/php.13256?af=R | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1111/php.13256 | pt |
degois.publication.volume | 96 | pt |
dc.date.embargo | 2020-12-31 | * |
uc.date.periodoEmbargo | 365 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-5165-5849 | - |
crisitem.author.orcid | 0000-0002-9339-7259 | - |
crisitem.author.orcid | 0000-0002-3223-4819 | - |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Rocha-photochemistryandphotobiology.pdf | 971.47 kB | Adobe PDF | Ver/Abrir |
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