Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/90485
Title: Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension
Authors: Boia, Raquel 
Salinas-Navarro, Manuel
Gallego-Ortega, Alejandro
Galindo-Romero, Caridad
Aires, Inês D. 
Agudo-Barriuso, Marta
Ambrósio, António Francisco 
Vidal-Sanz, Manuel
Santiago, Ana Raquel 
Issue Date: 21-May-2020
Publisher: Springer Nature
Project: PD/BD/ 114115/2015 
PD/BD/127821/2016 
PTDC/NEU-OSD/3123/2014 
UID/NEU/04539/2013 
BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias 
UID/NEU/04539/2019 
UIDB/04539/2020 
UIDP/04539/2020 
FCOMP-01-0124- FEDER-028417 
POCI-01-0145-FEDER-007440 
Serial title, monograph or event: Cell Death & Disease
Volume: 11
Issue: 5
Abstract: Glaucoma is a progressive chronic retinal degenerative disease and a leading cause of global irreversible blindness.This disease is characterized by optic nerve damage and retinal ganglion cell (RGC) death. The current treatmentsavailable target the lowering of intraocular pressure (IOP), the main risk factor for disease onset and development.However, in some patients, vision loss progresses despite successful IOP control, indicating that new and effectivetreatments are needed, such as those targeting the neuroprotection of RGCs. Adenosine A3receptor (A3R) activationconfers protection to RGCs following an excitotoxic stimulus. In this work, we investigated whether the activation ofA3R could also afford protection to RGCs in the laser-induced ocular hypertension (OHT) model, a well-characterizedanimal model of glaucoma. The intravitreal injection of 2-Cl-IB-MECA, a selective A3R agonist, abolished the alterationsinduced by OHT in the negative and positive components of scotopic threshold response (STR) without changing a-and b-wave amplitudes both in scotopic and photopic conditions. Moreover, the treatment of OHT eyes with the A3Ragonist promoted the survival of RGCs, attenuated the impairment in retrograde axonal transport, and improved thestructure of the optic nerve. Taking into consideration the beneficial effects afforded by 2-Cl-IB-MECA, we can envisagethat A3R activation can be considered a good therapeutic strategy to protect RGCs from glaucomatous damage.
URI: https://hdl.handle.net/10316/90485
ISSN: 2041-4889
DOI: 10.1038/s41419-020-2593-y
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
10.1038_s41419-020-2593-y.pdf2.45 MBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

8
checked on Nov 17, 2022

WEB OF SCIENCETM
Citations 20

12
checked on May 2, 2023

Page view(s)

241
checked on Apr 9, 2024

Download(s)

159
checked on Apr 9, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons