Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/88152
Title: Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice
Authors: Marques, Ana Patrícia
Cunha-Santos, Janete
Leal, Helena
Sousa-Ferreira, Lígia 
Pereira de Almeida, Luís 
Cavadas, Cláudia 
Rosmaninho-Salgado, Joana 
Keywords: Dipeptidyl peptidase IV inhibitor; Extracellular matrix; Fibrosis; Neuropeptide Y; Obesity; Vildagliptin
Issue Date: Mar-2018
Abstract: During the development of obesity the expansion of white adipose tissue (WAT) leads to a dysregulation and an excessive remodeling of extracellular matrix (ECM), leading to fibrosis formation. These ECM changes have high impact on WAT physiology and may change obesity progression. Blocking WAT fibrosis may have beneficial effects on the efficacy of diet regimen or therapeutical approaches in obesity. Since dipeptidyl peptidase IV (DPP-IV) inhibitors prevent fibrosis in tissues, such as heart, liver and kidney, the objective of this study was to assess whether vildagliptin, a DPP-IV inhibitor, prevents fibrosis in WAT in a mouse model of obesity, and to investigate the mechanisms underlying this effect.
URI: https://hdl.handle.net/10316/88152
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2017.11.012
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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