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Title: TGF-β1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology
Authors: Serralheiro, Pedro M. Azevedo
Soares, Andreia M. 
Almeida, Carlos M. Costa 
Verde, Ignacio
Keywords: TGF-β1; chronic venous insufficiency; growth factors; inflammation; signal transduction
Issue Date: 26-Nov-2017
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 18
Place of publication or event: Basel, Switzerland
Abstract: Chronic venous insufficiency and varicose veins occur commonly in affluent countries and are a socioeconomic burden. However, there remains a relative lack of knowledge about venous pathophysiology. Various theories have been suggested, yet the molecular sequence of events is poorly understood. Transforming growth factor-beta one (TGF-β1) is a highly complex polypeptide with multifunctional properties that has an active role during embryonic development, in adult organ physiology and in the pathophysiology of major diseases, including cancer and various autoimmune, fibrotic and cardiovascular diseases. Therefore, an emphasis on understanding its signaling pathways (and possible disruptions) will be an essential requirement for a better comprehension and management of specific diseases. This review aims at shedding more light on venous pathophysiology by describing the TGF-β1 structure, function, activation and signaling, and providing an overview of how this growth factor and disturbances in its signaling pathway may contribute to specific pathological processes concerning the vessel wall which, in turn, may have a role in chronic venous insufficiency.
ISSN: 1422-0067
DOI: 10.3390/ijms18122534
Rights: openAccess
Appears in Collections:I&D CEIS20 - Artigos em Revistas Internacionais

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