Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/8515
Title: Stabilization of visual acuity with photodynamic therapy in eyes with chorioretinal anastomoses
Authors: Silva, Rufino M. 
Abreu, José R. Faria de 
Travassos, António 
Cunha-Vaz, José G. 
Issue Date: 2004
Citation: Graefe's Archive for Clinical and Experimental Ophthalmology. 242:5 (2004) 368-376
Abstract: Purpose(1) To evaluate, in a non-randomized, institutional, prospective study, the efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomoses (CRA). (2) To review, in a retrospective study and for comparison, the natural evolution of neovascular AMD eyes with CRA.MethodsProspective clinical and angiographic study of 17 consecutive eyes with CRA, treated with PDT. Retrospective clinical and angiographic study of the natural course of 17 consecutive patients with CRA. Masked best-corrected visual acuity (VA) and angiographic features at baseline and during the period of one year were evaluated.ResultsThe two groups presented similar characteristics at baseline regarding age, sex, initial VA, duration of follow-up and angiographic features. PDT-treated eyes showed, at 1-year follow-up, VA stabilization or improvement in 73.3% of the eyes, no cases with very severe VA loss, and no fluorescein leakage in 46.6% of the eyes. In contrast, at 1-year follow-up the natural evolution of CRA was characterized by severe or very severe VA loss in 69% of the eyes and statistically significant mean VA loss ( P=0.001) with persistence of fluorescein leakage in all cases.ConclusionThe natural history of AMD eyes with CRA leads to progressive and dramatic VA loss, which is associated with blindness in most of the cases. PDT with verteporfin can offer some benefit to these patients, allowing VA stabilization or improvement in more than two thirds of the cases, at one year.
URI: https://hdl.handle.net/10316/8515
DOI: 10.1007/s00417-003-0844-0
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
obra.pdf334.32 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

24
checked on Feb 19, 2024

WEB OF SCIENCETM
Citations 5

20
checked on Feb 2, 2024

Page view(s) 50

532
checked on Feb 20, 2024

Download(s)

316
checked on Feb 20, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.