Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8425
Title: Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: Family-based association study
Authors: Ambrósio, Alda M. 
Kennedy, James L. 
Macciardi, Fabio 
Coelho, Isabel 
Soares, Maria J. 
Oliveira, Catarina R. 
Pato, Carlos N. 
Issue Date: 2004
Citation: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 128B:1 (2004) 1-5
Abstract: Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT). Concerning 5-HT1Dbeta autoreceptor gene, also negative results was obtained in the analysis of the haplotypes with transmit. Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population. © 2004 Wiley-Liss, Inc.
URI: http://hdl.handle.net/10316/8425
DOI: 10.1002/ajmg.b.30023
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
obra.pdf69.26 kBAdobe PDFView/Open
Show full item record

Page view(s) 50

278
checked on Jul 15, 2019

Download(s) 10

1,781
checked on Jul 15, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.