Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/8394
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pereira, I. | - |
dc.contributor.author | Nunes, S. | - |
dc.contributor.author | Ribeiro, M. L. | - |
dc.contributor.author | Bernardes, R. | - |
dc.contributor.author | Cunha-Vaz, J. | - |
dc.date.accessioned | 2009-02-09T14:54:05Z | - |
dc.date.available | 2009-02-09T14:54:05Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Acta Ophthalmologica. 86:s243 (2008) 0-0 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/8394 | - |
dc.description.abstract | Purpose To determine risk markers for the development of clinically significant macular edema (CSME) needing photocoagulation treatment in type 2 diabetic patients with mild nonproliferative retinopathy (NPDR), during a 7-year period. Methods Fifty-one type 2 diabetic patients with mild NPDR, followed-up for 2 years as controls of diabetic retinopathy clinical trials, were selected. Patients underwent ophthalmological examinations every 6 months, including stereoscopic color fundus photography, fluorescein angiography and vitreous fluorophotometry, and were metabolically controlled. These patients were thereafter followed-up for the next 5 years by conventional general and ophthalmological care. Results At the end of the 7-year follow-up period, 8 patients developed CSME, needing photocoagulation treatment. These patients presented a higher microaneurysm (MA) formation rate at the first year of follow-up (p<0.001), a higher blood-retinal barrier (BRB) permeability value (p=0.042), an abnormal foveal avascular zone (FAZ) contour on fluorescein angiography (p=0.009) and a higher HbA1C level at baseline (p=0.001). Conclusion Microaneurysm formation rate higher or equal to 3 MA/year, BRB permeability values over or equal to 4.0 nm.s-1, evidence of abnormalities in the FAZ, and hemoglobin A1C levels at baseline, are risk markers for progression of NPDR to CSME in patients with type 2 diabetes. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Risk markers for progression of mild nonproliferative retinopathy to clinically significant macular edema in type 2 diabetic patients | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1111/j.1755-3768.2008.4414.x | en_US |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CIAS - Research Centre for Anthropology and Health | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-5964-5001 | - |
crisitem.author.orcid | 0000-0002-6677-2754 | - |
crisitem.author.orcid | 0000-0002-0947-9850 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
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