Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8313
Title: Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells
Authors: Rosmaninho-Salgado, Joana 
Araújo, Inês M. 
Álvaro, Ana Rita 
Duarte, Emília P. 
Cavadas, Cláudia 
Issue Date: 2007
Citation: Journal of Neurochemistry. 103:3 (2007) 896-903
Abstract: The adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release from mouse chromaffin cells. The stimulatory effect of NPY mediated by NPY Y1 receptor activation was lost in the absence of extracellular Ca2+. On the other hand, inhibition of nitric oxide synthase and guanylyl cyclase also decreased the stimulatory effect of NPY. Moreover, catecholamine release stimulated by NPY or by the nitric oxide donor (NOC-18) was inhibited by mitogen-activated protein kinase (MAPK) and protein kinase C inhibitors. In summary, in mouse chromaffin cells, NPY evokes catecholamine release by the activation the NPY Y1 receptor, in a Ca2+-dependent manner, by activating mitogen-activated protein kinase and promoting nitric oxide production, which in turn regulates protein kinase C and guanylyl cyclase activation.
URI: http://hdl.handle.net/10316/8313
DOI: 10.1111/j.1471-4159.2007.04899.x
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
obra.pdf244.22 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

11
checked on Feb 18, 2020

WEB OF SCIENCETM
Citations

10
checked on Feb 18, 2020

Page view(s) 5

1,096
checked on Mar 24, 2020

Download(s)

92
checked on Mar 24, 2020

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.