Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8263
Title: Probing pseudopolymorphic transitions in pharmaceutical solids using Raman spectroscopy: Hydration and dehydration of theophylline
Authors: Amado, Ana M. 
Nolasco, Mariela M. 
Ribeiro-Claro, Paulo J. A. 
Issue Date: 2007
Citation: Journal of Pharmaceutical Sciences. 96:5 (2007) 1366-1379
Abstract: Theophylline is known to undergo vapor phase induced hydrate-anhydrate pseudopolymorphic transformations, which can affect its bioavailability. In this work, the kinetics of the pseudopolymorphic transitions of theophylline crystals in different storage conditions is studied using a vibrational spectroscopic technique. While the hydration is a single-step process with a half-life time of ca. 5 h, the dehydration occurs through a two-step mechanism. In addition, the phase stability of hydrate-anhydrate systems in different relative humidity (RH) conditions was probed. The critical RH for anhydrous teophylline was found to be at ca. 79%, while the critical RH for dehydration is ca. 30%. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1366-1379, 2007
URI: http://hdl.handle.net/10316/8263
DOI: 10.1002/jps.20923
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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