Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/8259
Title: | Pseudopolymorphic transitions of niclosamide monitored by Raman spectroscopy | Authors: | Sardo, Mariana Amado, Ana M. Ribeiro-Claro, Paulo J. A. |
Issue Date: | 2008 | Citation: | Journal of Raman Spectroscopy. 9999:9999 (2008) n/a | Abstract: | Niclosamide suffers pseudopolymorphic transformations when exposed to different ambient conditions, which can lead to changes in its bioavailability. In this study, the kinetics of the pseudopolymorphic transitions of niclosamide crystals are characterized. FT-Raman spectroscopy is used to quantify the anhydrate and hydrate forms of niclosamide crystals, mostly because of its high sensitivity to the strong intermolecular interactions present in these systems. The samples are exposed to well-characterized relative humidity (RH) conditions during different periods of time and both water diffusion and polymorphic changes are monitored from the corresponding changes observed in the vibrational spectra. Both hydration and dehydration were found to be single-step processes, with a half-life time of ca. 142 and 63 h, respectively, at 24 °C. Copyright © 2008 John Wiley & Sons, Ltd. | URI: | https://hdl.handle.net/10316/8259 | DOI: | 10.1002/jrs.2058 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
Show full item record
SCOPUSTM
Citations
17
checked on Oct 14, 2024
WEB OF SCIENCETM
Citations
5
16
checked on Oct 2, 2024
Page view(s) 50
396
checked on Oct 15, 2024
Download(s)
318
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.