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Title: Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
Authors: Sarmento, Bruno 
Martins, Susana 
Ribeiro, António 
Veiga, Francisco 
Neufeld, Ronald 
Ferreira, Domingos 
Issue Date: 2006
Citation: International Journal of Peptide Research and Therapeutics. 12:2 (2006) 131-138
Abstract: The overall objective of our research is to produce polyanion/chitosan nanoparticulate oral delivery systems for insulin. Specific objectives of the present study were to study dextran sulfate or alginate complexation with chitosan on mean particle size, insulin association efficiency, loading capacity and release profile. Nanoparticles were formed by ionotropic complexation and coacervation between polyanions (dextran sulfate and alginate) and chitosan. Diameter was evaluated with photon correlation spectroscopy, polymer interaction was confirmed by DSC and FTIR and particle morphology was assessed by SEM and TEM. Mean nanoparticle diameter ranged from 423 to 850 nm, insulin association efficiency from 63 to 94% and loading capacity from 5 to 13%. Dextran sulfate provided highest insulin association efficiency and retention of insulin in gastric simulated conditions. These nanoparticle systems show promise as insulin and potentially other therapeutic polypeptides carriers.
DOI: 10.1007/s10989-005-9010-3
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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