Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7947
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brito, Paula | - |
dc.contributor.author | Simões, Núria | - |
dc.contributor.author | Almeida, Leonor | - |
dc.contributor.author | Dinis, Teresa | - |
dc.date.accessioned | 2009-02-17T10:49:01Z | - |
dc.date.available | 2009-02-17T10:49:01Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Apoptosis. 13:8 (2008) 1043-1053 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7947 | - |
dc.description.abstract | Abstract Resveratrol (3,4',5-trihydroxystilbene) is a phytochemical believed to be partly responsible for the cardioprotective effects of red wine due to its numerous biological activities. Here, we studied biochemical pathways underlying peroxynitrite-mediated apoptosis in endothelial cells and potential mechanisms responsible for resveratrol cytoprotective action. Peroxynitrite triggered endothelial cell apoptosis through caspases-8, -9 and -3 activation implying both mitochondrial and death receptor apoptotic pathways. Resveratrol was able to prevent peroxynitrite-induced caspases-3 and -9 activation, but not caspase-8 activation. Additionally, peroxynitrite increased intracellular levels of Bax without affecting those of Bcl-2, increasing consequently the Bax/Bcl-2 ratio. This ratio decreased when cells where pre-incubated with 10 and 50 µM resveratrol, mainly due to resveratrol ability per se to increase Bcl-2 intracellular levels without affecting Bax intracellular levels. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2 | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1007/s10495-008-0235-4 | en_US |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-7769-4712 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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