Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7898
Title: Chenodeoxycholate Is a Potent Inducer of the Permeability Transition Pore in Rat Liver Mitochondria
Authors: Rolo, Anabela 
Oliveira, Paulo 
Moreno, António 
Palmeira, Carlos 
Issue Date: 2001
Citation: Bioscience Reports. 21:1 (2001) 73-80
Abstract: Several reports support the concept that bile acids may be cytotoxic during cholestatic disease process by causing mitochondrial dysfunction. Here we report additional data and findings aimed at a better understanding of the involvement of the permeability transition pore (PTP) opening in bile acids toxicity. The mitochondrial PTP is implicated as a mediator of cell injury and death in many situations. In the presence of calcium and phosphate, chenodeoxycholic acid (CDCA) induced a permeability transition in freshly isolated rat liver mitochondria, characterized by membrane depolarization, release of matrix calcium, and osmotic swelling. All these events were blocked by cyclosporine A (CyA) and the calcium uniporter inhibitor ruthenium red (RR). The results suggest that CDCA increases the sensitivity of isolated mitochondria in vitro to the calcium-dependent induction of the PTP.
URI: http://hdl.handle.net/10316/7898
DOI: 10.1023/A:1010438202519
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
obra.pdf62.19 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

19
checked on Nov 8, 2019

WEB OF SCIENCETM
Citations

17
checked on Nov 7, 2019

Page view(s) 10

660
checked on Dec 4, 2019

Download(s)

18
checked on Dec 4, 2019

Google ScholarTM

Check

Altmetric

Dimensions


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.