Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7873
DC FieldValueLanguage
dc.contributor.authorCarvalho, Cristina-
dc.contributor.authorCorreia, Sónia-
dc.contributor.authorSantos, Maria-
dc.contributor.authorSeiça, Raquel-
dc.contributor.authorOliveira, Catarina-
dc.contributor.authorMoreira, Paula-
dc.date.accessioned2009-02-17T10:35:20Z-
dc.date.available2009-02-17T10:35:20Z-
dc.date.issued2008en_US
dc.identifier.citationMolecular and Cellular Biochemistry. 308:1 (2008) 75-83en_US
dc.identifier.urihttp://hdl.handle.net/10316/7873-
dc.description.abstractAbstract Metformin, a drug widely used in the treatment of type 2 diabetes, has recently received attention due to the new and contrasting findings regarding its effects on mitochondrial function. In the present study, we evaluated the effect of metformin in isolated rat liver mitochondria status. We observed that metformin concentrations =8 mM induce an impairment of the respiratory chain characterized by a decrease in RCR and state 3 respiration. However, only metformin concentrations =10 mM affect the oxidative phosphorylation system by decreasing the mitochondrial transmembrane potential and increasing the repolarization lag phase. Moreover, our results show that metformin does not prevent H2O2 production, neither protects against lipid peroxidation induced by the pro-oxidant pair ADP/Fe2+. In addition, we observed that metformin exacerbates Ca2+-induced permeability transition pore opening by decreasing the capacity of mitochondria to accumulate Ca2+ and increasing the oxidation of thiol groups. Taken together, our results show that metformin can promote liver mitochondria injury predisposing to cell death.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleMetformin promotes isolated rat liver mitochondria impairmenten_US
dc.typearticleen_US
dc.identifier.doi10.1007/s11010-007-9614-3en_US
uc.controloAutoridadeSim-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.deptFaculdade de Medicina, Universidade de Coimbra-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0001-5177-6747-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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