Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7829
Title: Carvedilol reduces mitochondrial damage induced by hypoxanthine/xanthine oxidase
Authors: Oliveira, Paulo 
Rolo, Anabela 
Palmeira, Carlos 
Moreno, António 
Issue Date: 2001
Citation: Cardiovascular Toxicology. 1:3 (2001) 205-213
Abstract: Abstract The cardioprotective properties of new pharmaceuticals such as carvedilol might be explained by enhanced mitochondrial protection. The aim of this work was to determine the role of carvedilol in the protection of heart mitochondria from oxidative damage induced by hypoxanthine/xanthine oxidase, a known source of oxidative stress in the vascular system. Carvedilol reduced oxidative-stress-induced mitochondrial injury, as seen by the delay in the loss of the mitochondrial transmembranar potential (??), the decrease in mitochondrial swelling, and the increase in mitochondrial calcium uptake. Carvedilol improved the mitochondrial respiratory activity in state III and offered an overall protection in the respiratory control and in the P/O ratios in mitochondria under oxidative stress. The data indicated that carvedilol was able to partly protect heart mitochondria from oxidative stress-induced damage. Our results suggest that mitochondria can be important targets for some cardioprotective pharmaceuticals.
URI: http://hdl.handle.net/10316/7829
DOI: 10.1385/CT:1:3:205
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
obra.pdf62.34 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

20
checked on Nov 8, 2019

Page view(s) 20

450
checked on Dec 10, 2019

Download(s)

19
checked on Dec 10, 2019

Google ScholarTM

Check

Altmetric

Dimensions


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.