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Title: Toxicity of MCPA on non-green potato tuber calli
Authors: Peixoto, Francisco 
Lopes, M. 
Madeira, Vítor 
Vicente, Joaquim 
Issue Date: 2008
Abstract: Abstract Growth of potato tuber calli cells (non-green) is inhibited by 4-chloro-2-methylphenoxyacetic acid (MCPA) as a consequence of perturbation of membrane integrity. MCPA also depresses ATP content with simultaneous increase of ADP and AMP, i.e., the energy charge is severely compromised. Cell redox state is also affected by MCPA, as a function of concentration. Up to 60 µM, MCPA stimulates glutathione reductase and glutathione transferase, whereas superoxide dismutase and catalase activities are not affected. However, 120 µM MCPA inhibits all these activities. Cell death challenged by MCPA is putatively related to disturbance of membrane integrity responsible for mitochondrial uncoupling with decrease of the energy charge and subsequent loss of ions and metabolites.
DOI: 10.1007/s11738-008-0207-x
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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