Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7578
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dc.contributor.authorToninello, Antonio-
dc.contributor.authorBattaglia, Valentina-
dc.contributor.authorSalvi, Mauro-
dc.contributor.authorCalheiros, Rita-
dc.contributor.authorMarques, M. Paula M.-
dc.date.accessioned2009-02-17T10:18:51Z-
dc.date.available2009-02-17T10:18:51Z-
dc.date.issued2006en_US
dc.identifier.citationStructural Chemistry. 17:2 (2006) 163-175en_US
dc.identifier.urihttp://hdl.handle.net/10316/7578-
dc.description.abstractAbstract The present work aims at determining the structure–activity relationships (SAR’s) which rule the biological function of agmatine (4-(aminobutyl)guanidinium, AGM), a biogenic amine produced by decarboxylation of arginine. Its structural preferences, both as an isolated molecule and in aqueous solution (namely at physiological conditions) were ascertained, by vibrational (Raman) spectroscopy coupled to theoretical (density functional) calculations. An evaluation of mitochondrial functions (membrane potential (??), mitochondrial swelling, and cytochrome c release) in rat liver mitochondria (RLM) was also carried out. The results thus obtained, coupled to the conformational analysis performed for the distinct polyamine protonation states, allowed to individualize the agmatine structures which interact with the mitochondrial site responsible for its transport and for the protection against mitochondrial permeability transition (MPT) induction, as well as to gain information on the specific mechanisms involved.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleStructural characterization of agmatine at physiological conditionsen_US
dc.typearticleen_US
dc.identifier.doi10.1007/s11224-006-9025-1en_US
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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