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Title: Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity
Authors: Neves, André S. Campos 
Melo, Maria Luisa Sá e 
Moreno, Maria José S. M. 
Silva, Elisiário J. Tavares da 
Salvador, Jorge A. R. 
Costa, Saul P. da 
Martins, Rosa Maria L. M. 
Issue Date: 1999
Citation: Tetrahedron. 55:11 (1999) 3255-3264
Abstract: An Henbest reduction, followed by the preparation of a silyl enol ether and oxidation in situ with m-CPBA has led to the neurosteroids 3[alpha]-hydroxy- and 3[alpha],21-dihydroxy-5[alpha]-pregnanolones. Using testosterone as starting material, a new short synthesis of an aromatase inhibitor, 4-OHA, has been achieved through hydroboration/oxidation followed by a Swern type oxidation and epimerization. Another aromatase inhibitor, androst-4-ene-3,6-17-trione, has been efficiently prepared using PCC on montmorillonite K10, under ultrasonic irradiation.
DOI: 10.1016/S0040-4020(98)01138-7
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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