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https://hdl.handle.net/10316/5820
Title: | Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity | Authors: | Neves, André S. Campos Melo, Maria Luisa Sá e Moreno, Maria José S. M. Silva, Elisiário J. Tavares da Salvador, Jorge A. R. Costa, Saul P. da Martins, Rosa Maria L. M. |
Issue Date: | 1999 | Citation: | Tetrahedron. 55:11 (1999) 3255-3264 | Abstract: | An Henbest reduction, followed by the preparation of a silyl enol ether and oxidation in situ with m-CPBA has led to the neurosteroids 3[alpha]-hydroxy- and 3[alpha],21-dihydroxy-5[alpha]-pregnanolones. Using testosterone as starting material, a new short synthesis of an aromatase inhibitor, 4-OHA, has been achieved through hydroboration/oxidation followed by a Swern type oxidation and epimerization. Another aromatase inhibitor, androst-4-ene-3,6-17-trione, has been efficiently prepared using PCC on montmorillonite K10, under ultrasonic irradiation. | URI: | https://hdl.handle.net/10316/5820 | DOI: | 10.1016/S0040-4020(98)01138-7 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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