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https://hdl.handle.net/10316/5803
Title: | Lamotrigine analysis in blood and brain by high-performance liquid chromatography | Authors: | Castel-Branco, M. M. Almeida, A. M. Falcão, Amílcar Macedo, T. A. Caramona, M. M. Lopez, F. G. |
Keywords: | Lamotrigine | Issue Date: | 2001 | Citation: | Journal of Chromatography B: Biomedical Sciences and Applications. 755:1-2 (2001) 119-127 | Abstract: | A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins were previously precipitated with trichloroacetic acid. The method was linear between 0.1 and 15.0 mg/l for plasma, with a detection limit of 0.008 mg/l, and between 0.1 and 5.0 mg/l for brain homogenate, with a detection limit of 0.023 mg/l. The method proved to be simple, useful and appropriate, not only for clinical and experimental research, but also for routine monitoring of lamotrigine concentrations in patients. | URI: | https://hdl.handle.net/10316/5803 | DOI: | 10.1016/S0378-4347(01)00044-5 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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filef617ca2568c4433a8048679410c85902.pdf | 114.83 kB | Adobe PDF | View/Open |
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