Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5767| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Silva, M. Manuel Cruz | - |
| dc.contributor.author | Riva, Sergio | - |
| dc.contributor.author | Melo, M. Luísa Sá e | - |
| dc.date.accessioned | 2008-09-26T17:41:24Z | - |
| dc.date.available | 2008-09-26T17:41:24Z | - |
| dc.date.issued | 2004 | en_US |
| dc.identifier.citation | Tetrahedron: Asymmetry. 15:7 (2004) 1173-1179 | en_US |
| dc.identifier.uri | https://hdl.handle.net/10316/5767 | - |
| dc.description.abstract | Stereoisomerically pure 3[beta]-hydroxy-5,6-epoxysteroids were obtained by combining selective chemical methods for [alpha]- and [beta]-epoxidation of [Delta]5-unsaturated steroids with enzymatic stereoselective esterification of the 3[beta]-hydroxyl group. 5[beta],6[beta]-Epoxy-3[beta]-hydroxysteroids were efficiently acylated by Novozym 435 and lipase AK, whereas 5[alpha],6[alpha]-epoxy-3[beta]-hydroxysteroids were good substrates for Candida rugosa lipase. Mild enzymatic deacylation of the 3[beta]-acetoxy group in the presence of the epoxy functionality was also accomplished by C. rugosa lipase-mediated hydrolysis. | en_US |
| dc.description.uri | http://www.sciencedirect.com/science/article/B6THT-4BY3V2F-3/1/14f2ed3d64a39572337a2fd7eda27712 | en_US |
| dc.format.mimetype | aplication/PDF | en |
| dc.language.iso | eng | eng |
| dc.rights | openAccess | eng |
| dc.title | Highly selective lipase-mediated discrimination of diastereomeric 5,6-epoxysteroids | en_US |
| dc.type | article | en_US |
| dc.identifier.doi | 10.1016/j.tetasy.2004.02.010 | - |
| item.openairetype | article | - |
| item.fulltext | Com Texto completo | - |
| item.languageiso639-1 | en | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
| crisitem.author.orcid | 0000-0002-1938-4150 | - |
| Appears in Collections: | FFUC- Artigos em Revistas Internacionais | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| file76b01d72533f40a89f04b2e4320c4e33.pdf | 341.69 kB | Adobe PDF | View/Open |
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