Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5449
DC Field | Value | Language |
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dc.contributor.author | Fernandes, Maria A. S. | - |
dc.contributor.author | Geraldes, Carlos F. G. C. | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.contributor.author | Alpoim, Maria C. | - |
dc.date.accessioned | 2008-09-01T15:42:29Z | - |
dc.date.available | 2008-09-01T15:42:29Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Toxicology Letters. 114:1-3 (2000) 237-243 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5449 | - |
dc.description.abstract | In order to attenuate or to prevent chromate-induced human erythrocytes injury, the influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide on chromate-induced human erythrocytes haemoglobin oxidation and peroxidation were investigated. It was observed that pretreatment of human erythrocytes with vitamin E (20 [mu]M), vitamin C (1 mM), salicylate (3 mM), and deferoxamine (4 mM) significantly increased (P=0.0001) chromate-induced human erythrocytes haemoglobin oxidation in a time dependent manner, while it was significantly decreased (P=0.0001) by pretreatment with N-ethylmaleimide (1 mM). In contrast, pretreatment of human erythrocytes with deferoxamine (4 mM) immediately inhibited (P=0.0001) chromate-induced human erythrocytes peroxidation, while it was significantly increased (P=0.0001) by pretreatment with N-ethylmaleimide (1 mM) during the first 4 h of cells exposition to chromate. For time periods superior to 6 h pretreatment with N-ethylmaleimide (1 mM) significantly decreased (P=0.0001) chromate-induced human erythrocytes peroxidation. It was concluded that care must be taken as these drugs are used to prevent against toxicity induced by chromium(VI) compounds. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6TCR-3YS33K4-Y/1/25dfb55aba76e643521de990f45fb40e | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Antioxidants | en_US |
dc.subject | Chromate | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Haemoglobin oxidation | en_US |
dc.subject | Human erythrocytes | en_US |
dc.subject | Oxidative stress | en_US |
dc.title | Chromate-induced human erythrocytes haemoglobin oxidation and peroxidation: influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide | en_US |
dc.type | article | en_US |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-0837-8329 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
crisitem.author.orcid | 0000-0001-7273-9371 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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file70cbc12889b446ddb42a56dd67f069fb.pdf | 95.72 kB | Adobe PDF | View/Open |
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