Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5405
Title: Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol
Authors: Rolo, Anabela P. 
Oliveira, Paulo J. 
Moreno, António J. 
Palmeira, Carlos M. 
Keywords: Chenodeoxycholate; Carvedilol; Mitochondria; Cholestasis; Cardiomyopathy; Mitochondrial permeability transition; Membrane fluidity
Issue Date: 2003
Citation: Mitochondrion. 2:4 (2003) 305-311
Abstract: Chenodeoxycholate (CDCA) is a primary bile acid mostly implicated in cholestatic liver injury. In this study, we have investigated the involvement of membrane fluidity and cytochrome c release in CDCA-induced mitochondrial permeability transition (MPT), and the preventive role of carvedilol. Treatment of calcium-loaded hepatic mitochondria with CDCA was found to cause osmotic swelling and release of cytochrome c, associated with an increase in membrane fluidity, in both protein and lipid regions. Carvedilol and cyclosporine A (CyA) reduced both cytochrome c release and alterations in membrane fluidity induced by CDCA. The hydroxylated metabolite of carvedilol, BM-910228, had no effect. Thus, modulation of membrane fluidity, plays an important role in MPT pore opening promoted by CDCA. As a result, we have delineated a pathway for the preventive role of carvedilol in mitochondrial dysfunction induced by CDCA.
URI: http://hdl.handle.net/10316/5405
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file06f36e7a390746ecbc956630e97ceeba.pdf184.93 kBAdobe PDFView/Open
Show full item record

Page view(s) 10

677
checked on Jan 30, 2020

Download(s) 20

728
checked on Jan 30, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.