Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/5000
DC FieldValueLanguage
dc.contributor.authorSerra, A. C.-
dc.contributor.authorPineiro, M.-
dc.contributor.authorGonsalves, A. M. d'A. Rocha-
dc.contributor.authorAbrantes, M.-
dc.contributor.authorLaranjo, M.-
dc.contributor.authorSantos, A. C.-
dc.contributor.authorBotelho, M. F.-
dc.date.accessioned2008-09-01T15:02:12Z-
dc.date.available2008-09-01T15:02:12Z-
dc.date.issued2008en_US
dc.identifier.citationJournal of Photochemistry and Photobiology B: Biology. 92:1 (2008) 59-65en_US
dc.identifier.urihttps://hdl.handle.net/10316/5000-
dc.description.abstractBrominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TH0-4SCKRV7-2/1/f341bf72f1ad4338d46c1c71eadc64e3en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectHalogenated porphyrinsen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectHeavy atom effecten_US
dc.titleHalogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrinen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.jphotobiol.2008.04.006-
uc.controloAutoridadeSim-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-8664-2757-
crisitem.author.orcid0000-0002-7460-3758-
crisitem.author.orcid0000-0001-9987-7301-
crisitem.author.orcid0000-0003-0689-6007-
crisitem.author.orcid0000-0001-7202-1650-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
file34e77dbc443b4df6af05eecff958cade.pdf234.42 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

49
checked on Nov 9, 2022

WEB OF SCIENCETM
Citations

53
checked on May 2, 2023

Page view(s)

304
checked on Apr 16, 2024

Download(s)

325
checked on Apr 16, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.