Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4847
DC FieldValueLanguage
dc.contributor.authorPrata, M. I. M.-
dc.contributor.authorSantos, A. C.-
dc.contributor.authorGeraldes, C. F. G. C.-
dc.contributor.authorLima, J. J. P. de-
dc.date.accessioned2008-09-01T14:15:29Z-
dc.date.available2008-09-01T14:15:29Z-
dc.date.issued1999en_US
dc.identifier.citationNuclear Medicine and Biology. 26:6 (1999) 707-710en_US
dc.identifier.urihttp://hdl.handle.net/10316/4847-
dc.description.abstractThe 67Ga3+ complexes of three triazamacrocycles, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), its phosphonate analog 1,4,7-triazacyclononane-N,N',N''-tris(methylenephosphonic) acid (NOTP), and the monoethyl ester of NOTP, 1,4,7-triazacyclononane-N,N',N''-tris (methylenephosphonatemonoethylester) (NOTPME) were studied for possible use as radiopharmaceuticals. Biodistribution studies and gamma imaging were performed in Wistar rats. The present results demonstrated that all the macrocyclic complexes studied display renal clearance and are almost completely eliminated within 24 h. The [67Ga](NOTP)3- chelate, with a large negative charge, has a considerably slower uptake and elimination by the kidneys than the neutral [67Ga](NOTA) and [67Ga](NOTPME) chelates. We have thus demonstrated a charge-clearance relationship for a series of stable and well characterized complexes. The high stability and rapid renal excretion properties displayed by the NOTA and NOTPME chelates support their possible application as imaging agents for kidney structural and functional studies.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T9Y-3XCFK7N-H/1/af4cf25eeefdcee1bf9f29af66a68feden_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectRadiopharmaceuticalen_US
dc.subjectGamma imagingen_US
dc.subjectBiodistributionen_US
dc.subject67Ga3+ complexesen_US
dc.subjectTriazamacrocyclesen_US
dc.titleCharacterisation of 67Ga3+ complexes of triaza macrocyclic ligands: biodistribution and clearance studiesen_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.orcid0000-0002-0837-8329-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
file1b4fc689ad9e459989c015171a3bbbb4.pdf340.01 kBAdobe PDFView/Open
Show simple item record

Page view(s) 20

624
checked on Nov 11, 2019

Download(s) 20

967
checked on Nov 11, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.