Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4837
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dc.contributor.authorPrata, M. I. M.-
dc.contributor.authorSantos, A. C.-
dc.contributor.authorBligh, S. W. A.-
dc.contributor.authorChowdhury, A. H. M. S.-
dc.contributor.authorGeraldes, C. F. G. C.-
dc.contributor.authorLima, J. J. P. de-
dc.date.accessioned2008-09-01T14:15:19Z-
dc.date.available2008-09-01T14:15:19Z-
dc.date.issued2000en_US
dc.identifier.citationNuclear Medicine and Biology. 27:6 (2000) 605-610en_US
dc.identifier.urihttp://hdl.handle.net/10316/4837-
dc.description.abstractA large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with 111In3+. Two of the more hydrophobic compounds studied ([111In]L9 and [111In]L10) showed high affinity for human serum albumin (HSA). The biodistribution and clearance properties shown by all complexes upon injection in Wistar rats were followed by gamma imaging. The blood retention time of the chelates correlates better with their binding to HSA than with their hydrophilic/lipophilic ratio. Hydrophilic and negatively charged complexes undergo renal retention, while the majority of the lipophilic complexes are retained in the blood for a longer period of time and are cleared through the liver.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T9Y-43X3775-F/1/b025cc67d43a82f7dead68ec99e0f4bben_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAlbuminen_US
dc.subjectGamma imagingen_US
dc.subject111In3+ complexesen_US
dc.subjectDTPA derivativesen_US
dc.titleCharacterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imagingen_US
dc.typearticleen_US
dc.identifier.doi10.1016/S0969-8051(00)00127-X-
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0003-2888-0073-
crisitem.author.orcid0000-0002-0837-8329-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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