Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4791
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dc.contributor.authorAmbrósio, Alda M.-
dc.contributor.authorKennedy, James L.-
dc.contributor.authorMacciardi, Fabio-
dc.contributor.authorMacedo, António-
dc.contributor.authorValente, José-
dc.contributor.authorDourado, Ana-
dc.contributor.authorOliveira, Catarina R.-
dc.contributor.authorPato, Carlos-
dc.date.accessioned2008-09-01T14:14:32Z-
dc.date.available2008-09-01T14:14:32Z-
dc.date.issued2004en_US
dc.identifier.citationPsychiatry Research. 125:3 (2004) 185-191en_US
dc.identifier.urihttp://hdl.handle.net/10316/4791-
dc.description.abstractSchizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TBV-4C41P80-1/1/d79d43eb85579e44d4d3d0a2d108cf4aen_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectSchizophreniaen_US
dc.subjectAssociation studyen_US
dc.subjectCandidate genesen_US
dc.subjectLinkage disequilibriumen_US
dc.subjectHaplotypesen_US
dc.titleFamily association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese populationen_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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