Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/47553
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dc.contributor.authorMota, Paula C-
dc.contributor.authorCordeiro, Marília-
dc.contributor.authorPereira, Susana P-
dc.contributor.authorOliveira, Paulo J-
dc.contributor.authorMoreno, António J-
dc.contributor.authorRamalho-Santos, João-
dc.date.accessioned2018-02-12T13:22:17Z-
dc.date.available2018-02-12T13:22:17Z-
dc.date.issued2011-01-
dc.identifier.urihttp://hdl.handle.net/10316/47553-
dc.description.abstractThe release of environmental contaminants can contribute to impaired male fertility. The bioenergetics of isolated liver mitochondria have been used as a toxicological indicator, an inexpensive first line model to screen possible effects of several substances. Here we report the effects of 2,2-bis(4-chlorophenyl)-1,1-dichloro-ethylene (DDE) on the bioenergetical parameters of testicular mitochondria. A significant decrease in repolarization potential (after a phosphorylative cycle), state 3 respiration and uncoupled respiration, with a concomitant increase in lag phase was found, demonstrating a decrease in mitochondrial function. Importantly, there was also a clear increase in maximum potential in DDE-treated testis mitochondria, which was not mirrored by more commonly used liver mitochondria. Indeed, comparative studies showed that testis and liver mitochondria have strikingly different sensitivities and patterns of response to DDE, indicating that testis mitochondria should be used as a primary toxicological model for a proper evaluation of putative effects of environmental toxicants on the bioenergetics of spermatogenesis and male fertility.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAction Potentialspor
dc.subjectAnimalspor
dc.subjectDichlorodiphenyl Dichloroethylenepor
dc.subjectEndpoint Determinationpor
dc.subjectEnergy Metabolismpor
dc.subjectEnvironmental Pollutantspor
dc.subjectInsecticidespor
dc.subjectMalepor
dc.subjectMembrane Potential, Mitochondrialpor
dc.subjectMitochondria, Liverpor
dc.subjectOxygen Consumptionpor
dc.subjectProtonspor
dc.subjectRatspor
dc.subjectRats, Wistarpor
dc.subjectTestispor
dc.titleDifferential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicologypor
dc.typearticle-
degois.publication.firstPage80-5por
degois.publication.lastPage85por
degois.publication.issue1por
degois.publication.titleReproductive toxicology (Elmsford, N.Y.)por
dc.peerreviewedyespor
dc.identifier.doi10.1016/j.reprotox.2010.09.010por
degois.publication.volume31por
item.grantfulltextopen-
item.fulltextCom Texto completo-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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