Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/47463
Title: | Neural connectivity in youth at-risk for bipolar disorder: a review of functional magnetic resonance imaging studies | Authors: | Santos, Vítor Coroa, Manuel Caldeira, Salomé Bajouco, Miguel Madeira, Nuno |
Keywords: | Bipolar Disorder; At-Risk; Functional Connectivity; fMRI | Issue Date: | 15-Nov-2017 | Publisher: | ARC Publishing | Serial title, monograph or event: | Clinical Neurosciences and Mental Health | Volume: | S02 | Issue: | 4(Suppl.3) | Place of publication or event: | Porto | Abstract: | Background: Delayed diagnosis of bipolar disorder (BD) is common in adolescents and young adults and the search for biomarkers to help in early diagnosis in BD at-risk populations is an important goal of neuroimaging research. Functional connectivity studies in BD patients suggests that anomalous connectivity between prefrontal and limbic regions could be risk biomarkers for BD. The aim of this review is to provide an overview of the neuroimaging literature that employed functional connectivity techniques in adolescents and young adults at-risk for BD. Methods: A literature search was conducted using PubMed and EMBASE databases, to identify fMRI studies that em- ployed a measure of functional or e ective connectivity or network based statistics and included individuals at-risk for BD who were in the age range of early-mid adolescence (13–18 years old) and/or young adulthood (19–25 years old). Results: Ten studies focusing on 4 functional imaging domains were identi ed, namely emotion processing, a ective cognition, reward processing and resting-state. Altered functional connectivity between amygdala and ventrolateral prefrontal cortex (PFC); amygdala and anterior cingulate cortex and between anterior cingulate cortex, ventrolateral PFC and dorsolateral PFC emerged as putative risk biomarkers. Heterogeneity in BD at-risk samples, tasks and connectivity analysis methods has been identi ed. Conclusions: Youth at-risk for BD have altered functional connectivity in prefrontal-limbic networks supporting emo- tion regulation that might underlie emotion lability and mood dysregulation predisposing to BD. Future longitudinal studies in adolescents and young adults with Bipolar At-Risk criteria are important to establish functional connectivity measures as risk biomarkers. | URI: | https://hdl.handle.net/10316/47463 | DOI: | 10.21035/ijcnmh.2017.4(Suppl.3).S02 | Rights: | openAccess |
Appears in Collections: | I&D CINEICC - Artigos em Revistas Nacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Neural_connectivity_in_youth_at-risk_for_bipolar_d.pdf | 665.99 kB | Adobe PDF | View/Open |
Page view(s) 50
632
checked on Oct 15, 2024
Download(s) 50
415
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.