Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4712
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dc.contributor.authorProença, Paula-
dc.contributor.authorTeixeira, Helena-
dc.contributor.authorPinheiro, João-
dc.contributor.authorMonsanto, Paula V.-
dc.contributor.authorVieira, Duarte Nuno-
dc.date.accessioned2008-09-01T14:13:11Z-
dc.date.available2008-09-01T14:13:11Z-
dc.date.issued2007en_US
dc.identifier.citationForensic Science International. 170:2-3 (2007) 200-203en_US
dc.identifier.urihttp://hdl.handle.net/10316/4712-
dc.description.abstractTianeptine (Stablon®), although structurally similar to tricyclic antidepressants, acts by enhancing the reuptake of serotonin. A fatal case is presented involving a 26-year-old man, found lying in bed with a "mushroom of foam" around his mouth. Empty blister packs of Stablon® and a suicide note were found next to the body. A liquid-liquid extraction procedure with n-hexane: ethyl acetate and n-hexane: 2-propanol, followed by LC-DAD-MS analysis, using positive mode electrospray ionization was performed. The detection limit was 0.001 [mu]g/mL. The toxicological results revealed the following tianeptine concentrations in the post-mortem samples: blood 5.1 [mu]g/mL; urine 2.0 [mu]g/mL; liver 23 [mu]g/g; stomach contents 22 mg. Femoral blood analyses also revealed an ethanol concentration of 0.53 g/L. The present method was also developed and validated for the other post-mortem specimens, since no previous published data had confirmed the post-mortem distribution of tianeptine. The absence of other suitable direct causes of death (macroscopic or histological) and the positive results achieved with the toxicological analysis led the pathologist to rule that death was due to an intoxication caused by the suicidal ingestion of tianeptine in combination with alcohol.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T6W-4P5YK4N-5/1/f4c68b859971f524767ae38bfb681108en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectSuicideen_US
dc.subjectPoisoningen_US
dc.subjectTianeptineen_US
dc.subjectPost-mortem distributionen_US
dc.titleFatal intoxication with tianeptine (Stablon®)en_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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