Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/4706
Campo DC | Valor | Idioma |
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dc.contributor.author | Reis, F. | - |
dc.contributor.author | Lemos, E. Teixeira de | - |
dc.contributor.author | Almeida, L. | - |
dc.contributor.author | Parada, B. | - |
dc.contributor.author | Garrido, A. P. | - |
dc.contributor.author | Rocha-Pereira, P. | - |
dc.contributor.author | Santos-Silva, A. | - |
dc.contributor.author | Santos-Dias, J. | - |
dc.contributor.author | Dinis, A. | - |
dc.contributor.author | Figueiredo, A. | - |
dc.contributor.author | Costa-Almeida, C. | - |
dc.contributor.author | Mota, A. | - |
dc.contributor.author | Teixeira, F. | - |
dc.date.accessioned | 2008-09-01T14:13:04Z | - |
dc.date.available | 2008-09-01T14:13:04Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Transplantation Proceedings. 39:8 (2007) 2501-2506 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4706 | - |
dc.description.abstract | The present study sought to evaluate the prevention and reversion effects of isosorbide-5-mononitrate (Is-5-Mn) on the development of hypertension (HT) and on the underlying vascular and platelet morphofunctional disturbances, using an animal model of cyclosporine (CsA)-induced HT. The following rat groups (n = 8) were tested: (1) a control group (orange juice, for 7 weeks); (2) the CsA group (5 mg/kg/d for 7 weeks); (3) the Is-5-Mn group (150 mg/kg/d, twice a day for 7 weeks); (4) the prevention group (Is-5-Mn + CsA) treated for 2 weeks with Is-5-Mn only and thereafter with both drugs for 7 weeks; (5) the curative group (CsA + Is-5-Mn) beginning 7 weeks after CsA and following thereafter with both drugs for 5 weeks. Blood pressure, lipid profile, vascular lesion, platelet aggregation and morphology, and platelet thromboxane A2/vascular prostacyclin equilibrium were evaluated. Is-5-Mn + CsA therapy prevented (systolic blood pressure [SBP]: 114.3 ± 1.9 mm Hg, P < .001; diastolic blood pressure [DBP]: 97.0 ± 3.3 mm Hg, P < .001) the CsA-induced HT (SBP: 146.2 ± 4.5 mm Hg, P < .001; DBP: 124.9 ± 4.5 mm Hg, P < .001 vs control: SBP: 111.6 ± 0.7 mm Hg; DBP: 94.6 ± 1.0 mm Hg), as well as the vascular lesion and the platelet morphofunctional disturbances. The curative group did not show attenuated CsA-induced BP increase; it showed further enhancement of the HT effect (SBP: 159.7 ± 5.5 mm Hg, P < .05; DBP: 132.8 ± 2.8 mm Hg), as well as worsened vascular lesions and platelet function, namely a disruption in the TXA2/PGI2 equilibrium. Our data suggested that Is-5-Mn therapy may be a valid choice to prevent the morphofunctional changes associated with CsA-induced HT, when used as a preventive therapy. A careful evaluation of the impact of nitrate therapy should be considered, particularly the negative effect on cardiovascular hemodynamics, when considering its use after previous CsA disturbances have been established. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6VJ0-4PYHTPY-D/1/98d9093de8c6087fd26509f72f5803f7 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Dual Effect of Nitrate Therapy for Cyclosporine-Induced Hypertension on Vascular and Platelet Morphofunctional Markers; An Animal Model | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.transproceed.2007.07.029 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0002-9105-9619 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
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file888213d6346a42b29f1720c0df2ab748.pdf | 618.13 kB | Adobe PDF | Ver/Abrir |
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